Article

Loss of 5-Hydroxymethylcytosine as an Epigenetic Signature that Correlates with Poor Outcomes in Patients with Medulloblastoma

2020-08-05

Abstract excerpt

<h4>Background: </h4> Medulloblastoma, as the most common malignant brain tumor in children, exhibits highly dysregulated DNA methylation. The novel epigenetic marker—5-hydroxymethylcytosine (5hmC) plays essential role in gene regulation during brain development and in brain tumors. However, the biological and clinical implications of 5hmC in medulloblastoma are still unclear. <h4>Methods: </h4>: Here, we detected...

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Literature Corpus work: 7255635d-2852-5e96-923a-dc1415acd265
DOI: 10.21203/rs.3.rs-53498/v1

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