Article
Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.
Clinica chimica acta; international journal of clinical chemistry - 9 Oct 2012
Santonocito Concetta, Scapaticci Margherita, Penitente Romina, Paradisi Andrea, Capizzi Rodolfo, Lanza-Silveri Sara, Ficarra Silvana, Landi Francesco, Zuppi Cecilia, Capoluongo Ettore
Abstract excerpt
Base excision repair plays a key role in the removing of DNA damage from exposure to endogenous and exogenous carcinogens. The BER pathway removes alterations of a single oxidized, reduced or methylated base. Recently some studies have explored the association between risk for cutaneous melanoma and non-synonymous single-nucleotide polymorphisms (nsSNPs) in DNA-repair genes, although with contradictory results....
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