Genetic variation in DNA repair pathway genes and melanoma risk.

doi:10.1016/j.dnarep.2010.08.005

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Article

Genetic variation in DNA repair pathway genes and melanoma risk.

DNA repair - 2 Jan 2011

Zhang Mingfeng, Qureshi Abrar A, Guo Qun, Han Jiali

Abstract excerpt

Reduced DNA repair capacity has been proposed as a predisposing factor for melanoma. We comprehensively evaluated 1463 genetic variants across 60 DNA repair-related pathway genes in relation to melanoma risk in a nested case-control study of 218 melanoma cases (20% on head and neck) and 218 matched controls within the Nurses' Health Study (NHS). We then genotyped the two variants with the smallest P value in two...

Topics

Adult
Aged
Ataxia Telangiectasia Mutated Proteins
Case-Control Studies
Cell Cycle Proteins
Confidence Intervals
DNA Repair
DNA, Neoplasm
Female
Follow-Up Studies
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Head and Neck Neoplasms

Humans

Linkage Disequilibrium

Male

Melanoma

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 20837404
DOI: 10.1016/j.dnarep.2010.08.005
PMCID: PMC3010342

Genes

NHS
PARP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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