Article
Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma.
Mutation research - 30 Sept 2010
Figl Adina, Scherer Dominique, Nagore Eduardo, Bermejo Justo Lorenzo, Botella-Estrada Rafael, Gast Andreas, Thirumaran Ranjit K, Planelles Dolores, Hemminki Kari, Schadendorf Dirk, Kumar Rajiv
Abstract excerpt
Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant...
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