Article
DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma.
Carcinogenesis - 1 May 2007
Povey Joanne E, Darakhshan Fatemeh, Robertson Karen, Bisset Yvonne, Mekky Magda, Rees Jonathan, Doherty Val, Kavanagh Gina, Anderson Niall, Campbell Harry, MacKie Rona M, Melton David W
Abstract excerpt
The incidence of cutaneous melanoma is rising rapidly in a number of countries. The key environmental risk factor is exposure to the ultraviolet (UV) component in sunlight. The nucleotide excision repair (NER) pathway deals with the main forms of UV-induced DNA damage. We have investigated the hy...
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