Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.

doi:10.1158/1055-9965.EPI-05-0653

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Article

Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2006

Zhang Yawei, Newcomb Polly A, Egan Kathleen M, Titus-Ernstoff Linda, Chanock Stephen, Welch Robert, Brinton Louise A, Lissowska Jolanta, Bardin-Mikolajczak Alicja, Peplonska Beata, Szeszenia-Dabrowska Neonila, Zatonski Witold, Garcia-Closas Montserrat

Abstract excerpt

Impaired base-excision repair (BER) function can give rise to the accumulation of DNA damage and initiation of cancer. We evaluated whether genetic variation in six BER pathway genes (XRCC1, ADPRT, APEX1, OGG1, LIG3, and MUTYH) is associated with breast cancer risk in two large population-based case-control studies in the United States (3,368 cases and 2,880 controls) and Poland (1,995 cases and 2,296 controls)....

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Identifiers

PMID: 16492928
DOI: 10.1158/1055-9965.EPI-05-0653

Genes

XRCC1
APEX1
LIG3
MUTYH
OGG1

Variants

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Source receipt: pubmed, retrieved 7 Sept 2026.

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