Article
Single nucleotide polymorphisms in DNA repair genes XRCC1 and APEX1 in progression and survival of primary cutaneous melanoma patients.
Mutation research - 10 Feb 2009
Figl Adina, Scherer Dominique, Nagore Eduardo, Bermejo Justo Lorenzo, Dickes Elke, Thirumaran Ranjit K, Gast Andreas, Hemminki Kari, Kumar Rajiv, Schadendorf Dirk
Abstract excerpt
Single nucleotide polymorphisms, besides influencing susceptibility can potentially alter progression and survival in melanoma patients. In this study we evaluated the association of polymorphisms in the base-excision repair genes XRCC1 and APEX1 with overall survival (OS), metastasis-free survival (MFS) and survival following the first metastasis (SFM) in patients with cutaneous melanoma. We genotyped the D148E...
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