Article
Genetic polymorphisms in DNA repair and oxidative stress pathways associated with malignant melanoma susceptibility.
European journal of cancer (Oxford, England : 1990) - 1 Nov 2011
Ibarrola-Villava Maider, Peña-Chilet Maria, Fernandez Lara P, Aviles Jose A, Mayor Matias, Martin-Gonzalez Manuel, Gomez-Fernandez Cristina, Casado Beatriz, Lazaro Pablo, Lluch Ana, Benitez Javier, Lozoya Rafael, Boldo Enrique, Pizarro Angel, Martinez-Cadenas Conrado, Ribas Gloria
Abstract excerpt
BACKGROUND: Base excision repair (BER) and nucleotide excision repair (NER) pathways eliminate a wide variety of DNA damage, including UV photoproducts. The ability of each individual to repair DNA damage following different causes might explain at least in part the variability in cancer susceptibility. Moreover, inflammatory response to UV exposure may further contribute to skin carcinogenesis by oxidative...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
