Article
Evaluation of the role of LRRK2 gene in Parkinson's disease in an East Indian cohort.
Disease markers - 1 Jan 2012
Sadhukhan Tamal, Vishal Mansi, Das Gautami, Sharma Aanchal, Mukhopadhyay Arijit, Das Shyamal K, Ray Kunal, Ray Jharna
Abstract excerpt
Leucine rich repeat kinase 2 (LRRK2) gene defects cause Parkinson's disease (PD). Recently, LRRK2 has also been shown by genome wide association (GWA) studies to be a susceptibility gene for the disease. In India mutations in LRRK2 is a rare cause of PD. We, therefore, genotyped 64 SNPs across LRRK2 in 161 control samples and finally studied 6 haplotype tagging SNPs for association-based study on 300 cases and...
Topics
- Adult
- Age of Onset
- Aged
- Biomarkers
- Case-Control Studies
- Cohort Studies
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genetic Testing