Article
Evaluation of the role of LRRK2 gene in Parkinson's disease in an East Indian cohort.
Disease markers - 1 Jan 2012
Sadhukhan Tamal, Vishal Mansi, Das Gautami, Sharma Aanchal, Mukhopadhyay Arijit, Das Shyamal K, Ray Kunal, Ray Jharna
Abstract excerpt
Leucine rich repeat kinase 2 (LRRK2) gene defects cause Parkinson's disease (PD). Recently, LRRK2 has also been shown by genome wide association (GWA) studies to be a susceptibility gene for the disease. In India mutations in LRRK2 is a rare cause of PD. We, therefore, genotyped 64 SNPs across LRRK2 in 161 control samples and finally studied 6 haplotype tagging SNPs for association-based study on 300 cases and...
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