Article
Genetic variants ofLRRK2 in Taiwanese Parkinson's disease.
PloS one - 1 Jan 2013
Wu Yih-Ru, Chang Kuo-Hsuan, Chang Wen-Teng, Hsiao Ya-Chin, Hsu Hsuan-Chu, Jiang Pei-Ru, Chen Yi-Chun, Chao Chih-Ying, Chang Yi-Chung, Lee Bo-Hsun, Hu Fen-Ju, Chen Wan-Ling, Lee-Chen Guey-Jen, Chen Chiung-Mei
Abstract excerpt
Genetic variants of leucine-rich repeat kinase 2 (LRRK2) were reported to alter the risk for Parkinson's disease (PD). However, the genetic spectrum of LRRK2 variants has not been clearly disclosed yet in Taiwanese population. Herein, we sequenced LRRK2 coding region in 70 Taiwanese early onset PD patients (age at onset ≤ 50), and found six amino acid-changing single nucleotide polymorphisms (SNPs, N551K, R1398H,...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Asian People
- Female
- Gene Frequency
- Gene-Environment Interaction
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation, Missense