Article
Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus.
Arthritis and rheumatism - 1 Oct 2012
Cherian Tharian S, Kariuki Silvia N, Franek Beverly S, Buyon Jill P, Clancy Robert M, Niewold Timothy B
Abstract excerpt
OBJECTIVE: Variation in the interferon regulatory factor 5 (IRF5) gene has been associated with risk of developing systemic lupus erythematosus (SLE), and this association is largely dependent upon anti-Ro autoantibodies. This study was undertaken to determine if the IRF5 genotype is associated with maternal diagnosis or progression of autoimmunity. METHODS: Genotyping of haplotype-tagging polymorphisms in IRF5...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.