Article
Age at onset in LRRK2-associated PD is modified by SNCA variants.
Journal of molecular neuroscience : MN - 1 Sept 2012
Botta-Orfila Teresa, Ezquerra Mario, Pastor Pau, Fernández-Santiago Rubén, Pont-Sunyer Claustre, Compta Yaroslau, Lorenzo-Betancor Oswaldo, Samaranch Lluis, Martí Maria José, Valldeoriola Francesc, Calopa Matilde, Fernández Manel, Aguilar Miquel, de Fabregas Oriol, Hernández-Vara Jorge, Tolosa Eduard
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) and α-synuclein (SNCA) genes are known genetic causes of Parkinson's disease (PD). Recently, a genetic variant in SNCA has been associated with a lower age at onset in idiopathic PD (IPD). We genotyped the SNCA polymorphism rs356219 in 84 LRRK2-associated PD patients carrying the G2019S mutation. We found that a SNCA genetic variant is associated with an...
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