Article
Genomewide association study for onset age in Parkinson disease.
BMC medical genetics - 22 Sept 2009
Latourelle Jeanne C, Pankratz Nathan, Dumitriu Alexandra, Wilk Jemma B, Goldwurm Stefano, Pezzoli Gianni, Mariani Claudio B, DeStefano Anita L, Halter Cheryl, Gusella James F, Nichols William C, Myers Richard H, Foroud Tatiana
Abstract excerpt
BACKGROUND: Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age may represent invaluable therapeutic targets to delay the disease, we sought to identify such genetic modifiers using a genomewide association study in familial PD. There have been previous...
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