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Article

α-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2018

Fernández-Santiago Rubén, Garrido Alicia, Infante Jon, González-Aramburu Isabel, Sierra María, Fernández Manel, Valldeoriola Francesc, Muñoz Esteban, Compta Yaroslau, Martí María-José, Ríos José, Tolosa Eduardo, Ezquerra Mario

Abstract excerpt

OBJECTIVES: A recent study showed that Arab-Berbers GG homozygous at rs2421947(C/G) in the dynamin 3 gene (DNM3) had 12.5 years earlier age at onset of leucine-rich repeat kinase 2 (LRRK2)-associated Parkinson's disease (PD) (L2PD). We explored whether this variant modulates the L2PD age at onset in Spain. METHODS: We genotyped rs2421947 in 329 participants (210 L2PD patients, 119 L2PD nonmanifesting p.G2019S...

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Source

Identifiers

PMID: 29473656
DOI: 10.1002/mds.27295

Genes

DNM3
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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