Article
SNCA: major genetic modifier of age at onset of Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2013
Brockmann Kathrin, Schulte Claudia, Hauser Ann-Kathrin, Lichtner Peter, Huber Heiko, Maetzler Walter, Berg Daniela, Gasser Thomas
Abstract excerpt
Age at onset serves as a predictor of progression and mortality in sporadic Parkinson's disease (PD). Therefore, the identification of genetic modifiers for age at onset might lead to a better understanding of disease pathogenesis. We performed multivariate linear regression analysis in 1396 sporadic PD patients assessing 21 single-nucleotide polymorphisms (SNPs) that have been previously suggested to be...
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