The age at motor symptoms onset in LRRK2-associated Parkinson's disease is affected by a variation in the MAPT locus: a possible interaction.

doi:10.1007/s12031-011-9641-0

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Article

The age at motor symptoms onset in LRRK2-associated Parkinson's disease is affected by a variation in the MAPT locus: a possible interaction.

Journal of molecular neuroscience : MN - 1 Mar 2012

Gan-Or Ziv, Bar-Shira Anat, Mirelman Anat, Gurevich Tanya, Giladi Nir, Orr-Urtreger Avi

Abstract excerpt

The current paradigm on Parkinson's disease (PD) pathogenesis and course suggests the involvement of multiple genes and the interaction between them. Recently, it was reported that a variation (rs2435207) in the MAPT gene region influenced the age of motor symptoms onset (AO) in 44 PD patients from 19 families, carriers of leucine-rich repeat kinase 2 (LRRK2) mutations, all of European and North American origin....

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Identifiers

PMID: 21898123
DOI: 10.1007/s12031-011-9641-0

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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