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Article

Genetic factors influencing age at onset in LRRK2-linked Parkinson disease.

Parkinsonism & related disorders - 1 Aug 2009

Golub Yulia, Berg Daniela, Calne Donald B, Pfeiffer Ronald F, Uitti Ryan J, Stoessl A Jon, Wszolek Zbigniew K, Farrer Matthew J, Mueller Jakob C, Gasser Thomas, Fuchs Julia

Abstract excerpt

Patients with Leucine-rich repeat kinase 2 (LRRK2) linked Parkinson's disease (PD) clinically present with typical idiopathic PD. However, LRRK2-linked PD displays a pleomorphic neuropathology and high variability in age at disease onset (AAO) which suggests that environmental and/or genetic factors other than the mutation itself influence the course of the disease. We investigated the modulation of AAO by...

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Source

Identifiers

PMID: 19041274
DOI: 10.1016/j.parkreldis.2008.10.008

Genes

MAPT
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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