Article

A congenital pain insensitivity mutation in the nerve growth factor gene uncouples nociception from affective pain in heterozygous humans and mice

2018-05-25

Abstract excerpt

Pain is an unpleasant but necessary sensory experience, which facilitates adaptive behaviours, such as fear. Despite recent advances, the question of how the pain experience influences learning of the fear response is still debated 1,2 . Genetic disorders rendering patients congenitally unable to feel pain have been described, and are usually explained by defects in peripheral nociceptors 3-5 . It is not known h...

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Literature Corpus work: abb166f7-de41-5271-aff6-e4dffb25f73d
DOI: 10.1101/331587

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