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Article

Comparative genomic analysis of primary versus metastatic colorectal carcinomas.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2012

Vakiani Efsevia, Janakiraman Manickam, Shen Ronglai, Sinha Rileen, Zeng Zhaoshi, Shia Jinru, Cercek Andrea, Kemeny Nancy, D'Angelica Michael, Viale Agnes, Heguy Adriana, Paty Philip, Chan Timothy A, Saltz Leonard B, Weiser Martin, Solit David B

Abstract excerpt

PURPOSE: To compare the mutational and copy number profiles of primary and metastatic colorectal carcinomas (CRCs) using both unpaired and paired samples derived from primary and metastatic disease sites. PATIENTS AND METHODS: We performed a multiplatform genomic analysis of 736 fresh frozen CRC tumors from 613 patients. The cohort included 84 patients in whom tumor tissue from both primary and metastatic sites...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22665543
DOI: 10.1200/JCO.2011.38.2994
PMCID: PMC3417049

Genes

BRAF
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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