Article
Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing.
BMC cancer - 20 Jul 2018
Mogensen M B, Rossing M, Østrup O, Larsen P N, Heiberg Engel P J, Jørgensen L N, Hogdall E V, Eriksen J, Ibsen P, Jess P, Grauslund M, Nielsen H J, Nielsen F C, Vainer B, Osterlind K
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In order to assess the effectiveness of tailored treatment in regard to the primary tumour the differences in the genomic profile needs to be clarified. METHODS: Fresh-frozen tissue from primary...
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