Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High Concordance of Genomic Profiles between Primary and Metastatic Colorectal Cancer.

International journal of molecular sciences - 24 May 2021

Lee Seung Eun, Park Ha Young, Hwang Dae-Yong, Han Hye Seung

Abstract excerpt

The comparison of the genetic profiles between primary and metastatic colorectal cancer (CRC) is needed to enable the discovery of useful therapeutic targets against metastatic CRCs. We performed the targeted next generation sequencing assay of 170 cancer-associated genes for 142 metastatic CRCs, including 95 pairs of primary and metastatic CRCs, to reveal their genomic characteristics and to assess the genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to F-Box-WD Repeat-Containing Protein 7

Share to Genetic Profile

Share to Neoplasm Grading

Share to Neoplasm Metastasis

Share to Proto-Oncogene Proteins p21(ras)

Share to Smad4 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 34074070
DOI: 10.3390/ijms22115561
PMCID: PMC8197329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High Concordance of Genomic Profiles between Primary and Metastatic Colorectal Cancer.PMID 34074070Read ↗

Research progress on genetic heterogeneity between primary and paired metastatic colorectal cancer.Semantic proximity Read ↗

Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesionsSemantic proximity Read ↗

Genetic specificity study using next-generation sequencing (NGS) of peritoneal metastatic colorectal cancer compared to primary colorectal cancer.Semantic proximity Read ↗

Comparative Genomic Analysis of Primary and Synchronous Metastatic Colorectal CancersSemantic proximity Read ↗

Genetic Alterations of Metastatic Colorectal CancerSemantic proximity Read ↗

Characterization of genomic alterations in Chinese colorectal cancer patients with liver metastases.Semantic proximity Read ↗

Next-Generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas Demonstrates Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas.Semantic proximity Read ↗

Comprehensive Mutation Profiling of Colorectal Cancer Patients With Lung or Liver Metastasis by Targeted Next-Generation Sequencing.Semantic proximity Read ↗

Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.Semantic proximity Read ↗

Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer PatientsSemantic proximity Read ↗

Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer.Semantic proximity Read ↗

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.