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Article

Release factor one is nonessential in Escherichia coli.

ACS chemical biology - 17 Aug 2012

Johnson David B F, Wang Chong, Xu Jianfeng, Schultz Matthew D, Schmitz Robert J, Ecker Joseph R, Wang Lei

Abstract excerpt

Recoding a stop codon to an amino acid may afford orthogonal genetic systems for biosynthesizing new protein and organism properties. Although reassignment of stop codons has been found in extant organisms, a model organism is lacking to investigate the reassignment process and to direct code evolution. Complete reassignment of a stop codon is precluded by release factors (RFs), which recognize stop codons to...

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Identifiers

PMID: 22662873
DOI: 10.1021/cb300229q
PMCID: PMC3423824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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