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Article

Polypeptide release at sense and noncognate stop codons by localized charge-exchange alterations in translational release factors.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002

Uno Makiko, Ito Koichi, Nakamura Yoshikazu

Abstract excerpt

The mechanism of stop codon recognition during translation has long been a puzzle. Only recently has it been established that a tripeptide in the bacterial release factors (RFs) 1 and 2 serves as the "anticodon" in deciphering stop codons in mRNA. However, the molecular basis of the accuracy of stop codon recognition is unknown. Although specific tripeptides in the RFs are primarily responsible for selective...

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Identifiers

PMID: 11854484
DOI: 10.1073/pnas.032457599
PMCID: PMC122277

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