Article
Toward the experimental codon reassignment in vivo: protein building with an expanded amino acid repertoire.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 1999
Budisa N, Minks C, Alefelder S, Wenger W, Dong F, Moroder L, Huber R
Abstract excerpt
The high precision and fidelity of the genetic message transmission are ensured by numerous proofreading steps, from DNA replication and transcription to protein translation. The key event for translational fidelity is the proper codon assignment for 20 canonical amino acids. An experimental codo...
Topics
- Acylation
- Amino Acids
- Amino Acyl-tRNA Synthetases
- Codon
- Genetic Code
- Mutation
- Protein Biosynthesis
- Protein Engineering
- Protein Folding
- RNA Editing
- Ribosomes
- Substrate Specificity