Article
Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization.
Current biology : CB - 19 Jun 2012
Topalidou Irini, Keller Charles, Kalebic Nereo, Nguyen Ken C Q, Somhegyi Hannah, Politi Kristin A, Heppenstall Paul, Hall David H, Chalfie Martin
Abstract excerpt
BACKGROUND: Microtubules (MTs) are formed from the lateral association of 11-16 protofilament chains of tubulin dimers, with most cells containing 13-protofilament (13-p) MTs. How these different MTs are formed is unknown, although the number of protofilaments may depend on the nature of the α- and β-tubulins. RESULTS: Here we show that the enzymatic activity of the Caenorhabiditis elegans α-tubulin...
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