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Article

Allosteric conversation in the androgen receptor ligand-binding domain surfaces.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2012

Grosdidier Solène, Carbó Laia R, Buzón Víctor, Brooke Greg, Nguyen Phuong, Baxter John D, Bevan Charlotte, Webb Paul, Estébanez-Perpiñá Eva, Fernández-Recio Juan

Abstract excerpt

Androgen receptor (AR) is a major therapeutic target that plays pivotal roles in prostate cancer (PCa) and androgen insensitivity syndromes. We previously proposed that compounds recruited to ligand-binding domain (LBD) surfaces could regulate AR activity in hormone-refractory PCa and discovered several surface modulators of AR function. Surprisingly, the most effective compounds bound preferentially to a surface...

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Identifiers

PMID: 22653923
DOI: 10.1210/me.2011-1281
PMCID: PMC5416996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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