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Article

Evidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor.

Molecular and cellular biology - 1 Aug 2012

Helsen Christine, Dubois Vanessa, Verfaillie Annelien, Young Jacques, Trekels Mieke, Vancraenenbroeck Renée, De Maeyer Marc, Claessens Frank

Abstract excerpt

DNA binding as well as ligand binding by nuclear receptors has been studied extensively. Both binding functions are attributed to isolated domains of which the structure is known. The crystal structure of a complete receptor in complex with its ligand and DNA-response element, however, has been solved only for the peroxisome proliferator-activated receptor γ (PPARγ)-retinoid X receptor α (RXRα) heterodimer. This...

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Identifiers

PMID: 22645304
DOI: 10.1128/MCB.00151-12
PMCID: PMC3434514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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