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Article

The T850D Phosphomimetic Mutation in the Androgen Receptor Ligand Binding Domain Enhances Recruitment at Activation Function 2.

International journal of molecular sciences - 29 Jan 2022

Helsen Christine, Nguyen Tien, Vercruysse Thomas, Wouters Staf, Daelemans Dirk, Voet Arnout, Claessens Frank

Abstract excerpt

Several key functions of the androgen receptor (AR) such as hormone recognition and co-regulator recruitment converge in the ligand binding domain (LBD). Loss- or gain-of-function of the AR contributes to pathologies such as the androgen insensitivity syndrome and prostate cancer. Here, we describe a gain-of-function mutation of the surface-exposed threonine at position 850, located at the amino-terminus of Helix...

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Identifiers

PMID: 35163481
DOI: 10.3390/ijms23031557
PMCID: PMC8836279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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