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Article

A conserved surface on the ligand binding domain of nuclear receptors for allosteric control.

Molecular and cellular endocrinology - 30 Jan 2012

Buzón Víctor, Carbó Laia R, Estruch Sara B, Fletterick Robert J, Estébanez-Perpiñá Eva

Abstract excerpt

Nuclear receptors (NRs) form a large superfamily of transcription factors that participate in virtually every key biological process. They control development, fertility, gametogenesis and are misregulated in many cancers. Their enormous functional plasticity as transcription factors relates in part to NR-mediated interactions with hundreds of coregulatory proteins upon ligand (e.g., hormone) binding to their...

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Identifiers

PMID: 21878368
DOI: 10.1016/j.mce.2011.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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