Article
Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif.
The Journal of biological chemistry - 28 Mar 2014
Jehle Katja, Cato Laura, Neeb Antje, Muhle-Goll Claudia, Jung Nicole, Smith Emmanuel W, Buzon Victor, Carbó Laia R, Estébanez-Perpiñá Eva, Schmitz Katja, Fruk Ljiljana, Luy Burkhard, Chen Yu, Cox Marc B, Bräse Stefan, Brown Myles, Cato Andrew C B
Abstract excerpt
The androgen receptor (AR) is a ligand-activated transcription factor that is essential for prostate cancer development. It is activated by androgens through its ligand-binding domain (LBD), which consists predominantly of 11 α-helices. Upon ligand binding, the last helix is reorganized to an agonist conformation termed activator function-2 (AF-2) for coactivator binding. Several coactivators bind to the AF-2...
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