Article
Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2001
Buchanan G, Yang M, Harris J M, Nahm H S, Han G, Moore N, Bentel J M, Matusik R J, Horsfall D J, Marshall V R, Greenberg N M, Tilley W D
Abstract excerpt
The androgen receptor (AR), a member of the steroid receptor superfamily of nuclear transcription factors, mediates androgen signaling in diverse target tissues. Here we report AR gene mutations identified in human prostate cancer and the autochthonous transgenic adenocarcinoma of the mouse prostate model that colocate to residues (668)QPIF(671) at the boundary of the hinge and ligand-binding domain, resulting in...
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