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Article

Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.

Journal of medicinal chemistry - 22 Dec 2011

Lack Nathan A, Axerio-Cilies Peter, Tavassoli Peyman, Han Frank Q, Chan Ka Hong, Feau Clementine, LeBlanc Eric, Guns Emma Tomlinson, Guy R Kiplin, Rennie Paul S, Cherkasov Artem

Abstract excerpt

The androgen receptor (AR) is the best studied drug target for the treatment of prostate cancer. While there are a number of drugs that target the AR, they all work through the same mechanism of action and are prone to the development of drug resistance. There is a large unmet need for novel AR inhibitors which work through alternative mechanism(s). Recent studies have identified a novel site on the AR called...

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Share to Androgen Antagonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Androgen

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Identifiers

PMID: 22047606
DOI: 10.1021/jm201098n
PMCID: PMC3668559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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