Article
Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis.
Circulation research - 12 Sept 2008
Kisucka Janka, Chauhan Anil K, Patten Ian S, Yesilaltay Ayce, Neumann Carola, Van Etten Richard A, Krieger Monty, Wagner Denisa D
Abstract excerpt
The peroxiredoxin (Prdx) family of antioxidant enzymes uses redox-active cysteines to reduce peroxides, lipid hydroperoxides, and peroxynitrites. Prdx1 is known to be important to protect red blood cells against reactive oxygen species and in tumor prevention. In this study, the role of Prdx1 in inflammation, thrombosis, and atherosclerosis was investigated. Using intravital microscopy, we showed that the number...
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