Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2017

Dhanesha Nirav, Doddapattar Prakash, Chorawala Mehul R, Nayak Manasa K, Kokame Koichi, Staber Janice M, Lentz Steven R, Chauhan Anil K

Abstract excerpt

OBJECTIVE: ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type I repeats-13) prevents microvascular thrombosis by cleaving prothrombogenic ultralarge von Willebrand factor (VWF) multimers. Clinical studies have found association between reduced ADAMTS13-specific activity, ultralarge VWF multimers, and thrombotic angiopathy in patients with diabetic nephropathy. It remains unknown, however,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAMTS13 Protein
Share to Albuminuria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Creatinine

Share to Diabetes Mellitus, Experimental

Share to Kidney Glomerulus

Share to Plasminogen Activator Inhibitor 1

Share to Streptozocin

Source

Open in PubMed Open full text

Identifiers

PMID: 28495930
DOI: 10.1161/ATVBAHA.117.309539
PMCID: PMC5501287

Genes

VWF
ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice.PMID 28495930Read ↗

ADAMTS13 predicts renal and cardiovascular events in type 2 diabetic patients and response to therapy.Semantic proximity Read ↗

Phenotypic expression of ADAMTS13 in glomerular endothelial cells.Semantic proximity Read ↗

Genetic Ablation of <i>Adamts13</i> Gene Dramatically Accelerates the Formation of Early Atherosclerosis in a Murine ModelSemantic proximity Read ↗

The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formationSemantic proximity Read ↗

Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy.Semantic proximity Read ↗

A plasminogen activator inhibitor type 1 mutant retards diabetic nephropathy in db/db mice by protecting podocytes.Semantic proximity Read ↗

Cardiovascular manifestations of renovascular hypertension in diabetic miceSemantic proximity Read ↗

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplaySemantic proximity Read ↗

Mechanisms of microvascular thrombosis in thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

ADAM17 Deletion Protects Against Type1 Diabetes-Associated Kidney Injury by Modulating Inflammatory and Fibrotic PathwaysSemantic proximity Read ↗

Role of fibrillin-1 in hypertensive and diabetic glomerular disease.Semantic proximity Read ↗

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.