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Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice.

Thrombosis and haemostasis - 5 Jan 2017

Vorlova Sandra, Koch Miriam, Manthey Helga D, Cochain Clement, Busch Martin, Chaudhari Sweena M, Stegner David, Yepes Manuel, Lorenz Kristina, Nolte Marc W, Nieswandt Bernhard, Zernecke Alma

Abstract excerpt

Atherosclerosis is considered a chronic inflammatory disease of the vessel wall. Coagulation pathways and immune responses contribute to disease development. The role of coagulation factor XII (FXII) in vascular inflammation, however, remains controversial. We here investigated the function of FXII in atherosclerosis using apolipoprotein E and FXII-deficient (F12-/-Apoe-/-) mice. Compared to F12+/+Apoe-/-...

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Antigen-Presenting Cells
Aortic Diseases
Factor XII
Inflammation Mediators
Mice, Knockout, ApoE

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plaque, Atherosclerotic

Receptors, Urokinase Plasminogen Activator

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PMID: 27786338
DOI: 10.1160/TH16-06-0466

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