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Article

A common polymorphism in the ABCB1 gene is associated with side effects of PGP-dependent antidepressants in a large naturalistic Dutch cohort.

The pharmacogenomics journal - 1 Apr 2016

Bet P M, Verbeek E C, Milaneschi Y, Straver D B M, Uithuisje T, Bevova M R, Hugtenburg J G, Heutink P, Penninx B W J H, Hoogendijk W J G

Abstract excerpt

The drug efflux transporter permeability glycoprotein (PGP) and cytochrome P450 (CYP) 2C19 are important for eliminating antidepressants from the brain and body. The ABCB1 gene, encoding for PGP, and CYP2C19 gene have several variants that could influence enzyme function and thereby the effect of PGP- and 2C19-dependent antidepressants. We investigated the association of antidepressant side effect and common...

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Share to Antidepressive Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytochrome P-450 CYP2C19

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 25987242
DOI: 10.1038/tpj.2015.38

Genes

PGP
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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