Mutant G-protein-coupled receptors as a cause of human diseases.

doi:10.1016/j.pharmthera.2004.08.008

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Mutant G-protein-coupled receptors as a cause of human diseases.

Pharmacology & therapeutics - 1 Dec 2004

Schöneberg Torsten, Schulz Angela, Biebermann Heike, Hermsdorf Thomas, Römpler Holger, Sangkuhl Katrin

Abstract excerpt

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an extraordinary variety of physiological functions. Their key roles in cellular communication have made them the target for more than 60% of all currently prescribed drugs. Mutations in GPCR can cause acquired and inherited diseases such as retinitis pigmentosa (RP), hypo- and hyperthyroidism, nephrogenic diabetes insipidus,...

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Mutant G-protein-coupled receptors as a cause of human diseases.

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Mutant G-protein-coupled receptors as a cause of human diseases.

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