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Article

FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21

1 Aug 2013

Abstract excerpt

We have identified the human FMN2 gene as a novel target regulated by induction of p14ARF and by multiple other stress responses, including DNA damage and hypoxia, which have in common activation of cell cycle arrest. We showed that increased expression of the FMN2 gene following p14ARF induction is caused, at the transcriptional level, by relief of repression by RelA and E2F1, which, under non-induced...

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PMID: 23839046
DOI: 10.4161/cc.25511

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