Article
The RAF cysteine-rich domain: Structure, function, and role in disease.
Advances in cancer research - 1 Jan 2024
Spencer-Smith Russell
Abstract excerpt
RAF kinases, consisting of ARAF, BRAF and CRAF, are direct effectors of RAS GTPases and critical for signal transduction through the RAS-MAPK pathway. Driver mutations in BRAF are commonplace in human cancer, while germline mutations in BRAF and CRAF cause RASopathy development syndromes. However, there remains a lack of effective drugs that target RAF function, which is partially due to the complexity of the RAF...
Topics
- Humans
- Neoplasms
- Animals
- raf Kinases
- Protein Domains
- Cysteine
- Mutation
- Signal Transduction
- Structure-Activity Relationship