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Article

Acetylation-dependent regulation of BRAF oncogenic function.

Cell reports - 18 Jan 2022

Dai Xiangpeng, Zhang Xiaoling, Yin Qing, Hu Jia, Guo Jianping, Gao Yang, Snell Aidan H, Inuzuka Hiroyuki, Wan Lixin, Wei Wenyi

Abstract excerpt

Aberrant BRAF activation, including the BRAFV600E mutation, is frequently observed in human cancers. However, it remains largely elusive whether other types of post-translational modification(s) in addition to phosphorylation and ubiquitination-dependent regulation also modulate BRAF kinase activity. Here, we report that the acetyltransferase p300 activates the BRAF kinase by promoting BRAF K601 acetylation, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35045286
DOI: 10.1016/j.celrep.2021.110250
PMCID: PMC8813213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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