Article
Characterization of in vitro and in vivo mutations in non-conserved nucleotides in the ribosomal RNA recognition domain for the ribotoxins ricin and sarcin and the translation elongation factors.
Journal of molecular biology - 15 Jan 1999
Macbeth M R, Wool I G
Abstract excerpt
The sarcin/ricin domain in 23 S/28 S rRNA is crucial for ribosome function, since it constitutes at least part of the binding site for the elongation factors and hence is essential for binding aminoacyl-tRNA and for translocation. The domain is also the site of action of ricin and sarcin and anal...
Topics
- Animals
- Base Sequence
- Binding Sites
- Catalysis
- Endoribonucleases
- Escherichia coli
- Fungal Proteins
- Molecular Sequence Data
- Mutagenesis
- Nucleic Acid Conformation
- Nucleotides
- Peptide Elongation Factor G
- Peptide Elongation Factors
- Phenotype
- Plasmids
- Protein Biosynthesis
- RNA, Bacterial
- RNA, Ribosomal, 23S