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Phosphorylation of Mycobacterial PcaA Inhibits Mycolic Acid Cyclopropanation

24 May 2012

Abstract excerpt

Pathogenic mycobacteria survive within macrophages by residing in phagosomes, which they prevent from maturing and fusing with lysosomes. Although several bacterial components were seen to modulate phagosome processing, the molecular regulatory mechanisms taking part in this process remain elusive. We investigated whether the phagosome maturation block (PMB) could be modulated by signaling through Ser/Thr...

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PMID: 22621931
DOI: 10.1074/jbc.m112.373209

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