Article
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.
The Journal of biological chemistry - 6 Mar 2009
Veyron-Churlet Romain, Molle Virginie, Taylor Rebecca C, Brown Alistair K, Besra Gurdyal S, Zanella-Cléon Isabelle, Fütterer Klaus, Kremer Laurent
Abstract excerpt
Mycolic acids are hallmark features of the Mycobacterium tuberculosis cell wall. They are synthesized by the condensation of two fatty acids, a C56-64-meromycolyl chain and a C24-26-fatty acyl chain. Meromycolates are produced via the combination of type I and type II fatty acid synthases (FAS-I and FAS-II). The beta-ketoacyl-acyl carrier protein (ACP) synthase III (mtFabH) links FAS-I and FAS-II, catalyzing the...
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