Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid.

The Journal of biological chemistry - 7 Mar 2003

Glickman Michael S

Abstract excerpt

Infection with Mycobacterium tuberculosis (Mtb) remains a severe global health problem that has prompted an aggressive search for new antibiotic targets and vaccine strategies for this persistent pathogen. Recently, a wide variety of genetic determinants of Mtb pathogenicity have been identified, including several genes involved in the biogenesis of the complex Mtb cell envelope. Among these are the mycolic acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Genes, Bacterial
Share to Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Mycobacterium research and diagnosis

Share to Mycobacterium tuberculosis

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Tuberculosis Research and Epidemiology

Source

Identifiers

PMID: 12502719
DOI: 10.1074/jbc.M212458200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid.PMID 12502719Read ↗

The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase.Semantic proximity Read ↗

The Biosynthesis of Cyclopropanated Mycolic Acids in Mycobacterium tuberculosisSemantic proximity Read ↗

The Molecular Genetics of Mycolic Acid BiosynthesisSemantic proximity Read ↗

Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis.Semantic proximity Read ↗

Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.Semantic proximity Read ↗

Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice.Semantic proximity Read ↗

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in MycobacteriaSemantic proximity Read ↗

Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in MycobacteriaSemantic proximity Read ↗

Evolution of Mycolic Acid Biosynthesis Genes and Their Regulation during Starvation in Mycobacterium tuberculosisSemantic proximity Read ↗

Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule.Semantic proximity Read ↗

Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. Structural analysis of fatty acids of a mutant strain deviod of methoxy- and ketomycolates.Semantic proximity Read ↗

Inactivation of tesA Reduces Cell Wall Lipid Production and Increases Drug Susceptibility in MycobacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.