Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule.

Abstract excerpt

Mycobacterium tuberculosis (Mtb) infection remains a global health crisis. Recent genetic evidence implicates specific cell envelope lipids in Mtb pathogenesis, but it is unclear whether these cell envelope compounds affect pathogenesis through a structural role in the cell wall or as pathogenesis effectors that interact directly with host cells. Here we show that cyclopropane modification of the Mtb cell...

Topics

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• Colony Count, Microbial
• Cyclopropanes
• Immunity, Innate
• Interleukin-6
• Macrophage Activation