Article
Temperature-dependent regulation of mycolic acid cyclopropanation in saprophytic mycobacteria: role of the Mycobacterium smegmatis 1351 gene (MSMEG_1351) in CIS-cyclopropanation of alpha-mycolates.
The Journal of biological chemistry - 9 Jul 2010
Alibaud Laeticia, Alahari Anuradha, Trivelli Xavier, Ojha Anil K, Hatfull Graham F, Guerardel Yann, Kremer Laurent
Abstract excerpt
The cell envelope is a crucial determinant of virulence and drug resistance in Mycobacterium tuberculosis. Several features of pathogenesis and immunomodulation of host responses are attributable to the structural diversity in cell wall lipids, particularly in the mycolic acids. Structural modifi...
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