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Article

Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.

Cancer research - 15 Aug 2012

Szabova Ludmila, Yin Chaoying, Bupp Sujata, Guerin Theresa M, Schlomer Jerome J, Householder Deborah B, Baran Maureen L, Yi Ming, Song Yurong, Sun Wenping, McDunn Jonathan E, Martin Philip L, Van Dyke Terry, Difilippantonio Simone

Abstract excerpt

The majority of human high-grade serous epithelial ovarian cancer (SEOC) is characterized by frequent mutations in p53 and alterations in the RB and FOXM1 pathways. A subset of human SEOC harbors a combination of germline and somatic mutations as well as epigenetic dysfunction for BRCA1/2. Using Cre-conditional alleles and intrabursal induction by Cre-expressing adenovirus in genetically engineered mice, we...

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Source

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Identifiers

PMID: 22617326
DOI: 10.1158/0008-5472.CAN-11-3834
PMCID: PMC3421072

Genes

BRCA1
FOXM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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