Article
Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.
PloS one - 1 Jan 2014
Szabova Ludmila, Bupp Sujata, Kamal Muhaymin, Householder Deborah B, Hernandez Lidia, Schlomer Jerome J, Baran Maureen L, Yi Ming, Stephens Robert M, Annunziata Christina M, Martin Philip L, Van Dyke Terry A, Weaver Ohler Zoe, Difilippantonio Simone
Abstract excerpt
The high mortality rate from ovarian cancers can be attributed to late-stage diagnosis and lack of effective treatment. Despite enormous effort to develop better targeted therapies, platinum-based chemotherapy still remains the standard of care for ovarian cancer patients, and resistance occurs at a high rate. One of the rate limiting factors for translation of new drug discoveries into clinical treatments has...
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