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Article

Pathway-level mutation analysis in primary high-grade serous ovarian cancer and matched brain metastases.

Scientific reports - 29 Nov 2022

Duchnowska Renata, Supernat Anna Maria, Pęksa Rafał, Łukasiewicz Marta, Stokowy Tomasz, Ronen Roy, Dutkowski Janusz, Umińska Monika, Iżycka-Świeszewska Ewa, Kowalczyk Anna, Och Waldemar, Rucińska Monika, Olszewski Wojciech P, Mandat Tomasz, Jarosz Bożena, Bieńkowski Michał, Biernat Wojciech, Jassem Jacek

Abstract excerpt

Brain metastases (BMs) in ovarian cancer (OC) are a rare event. BMs occur most frequently in high-grade serous (HGS) OC. The molecular features of BMs in HGSOC are poorly understood. We performed a whole-exome sequencing analysis of ten matched pairs of formalin-fixed paraffin-embedded samples from primary HGSOC and corresponding BMs. Enrichment significance (p value; false discovery rate) was computed using the...

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Identifiers

PMID: 36446793
DOI: 10.1038/s41598-022-23788-4
PMCID: PMC9708673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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