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Modeling High-Grade Serous Ovarian Carcinoma Using a Combination of In Vivo Fallopian Tube Electroporation and CRISPR-Cas9-Mediated Genome Editing.

Cancer research - 15 Oct 2021

Teng Katie, Ford Matthew J, Harwalkar Keerthana, Li YuQi, Pacis Alain S, Farnell David, Yamanaka Nobuko, Wang Yu-Chang, Badescu Dunarel, Ton Nu Tuyet Nhung, Ragoussis Jiannis, Huntsman David G, Arseneau Jocelyne, Yamanaka Yojiro

Abstract excerpt

Ovarian cancer is the most lethal gynecologic cancer to date. High-grade serous ovarian carcinoma (HGSOC) accounts for most ovarian cancer cases, and it is most frequently diagnosed at advanced stages. Here, we developed a novel strategy to generate somatic ovarian cancer mouse models using a combination of in vivo electroporation and CRISPR-Cas9-mediated genome editing. Mutation of tumor suppressor genes...

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Source

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Identifiers

PMID: 34301761
DOI: 10.1158/0008-5472.CAN-20-1518
PMCID: PMC9397628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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